Title
Azaphilones isolated from an alga-derived fungus Penicillium sp. ZJ-27
Author
Liu-hong Zhang, Yi Long, Xiao-ling Lei, Jia-yi Xu, Zhi-jian Huang, Zhi-gang She, Yong-cheng Lin, Jing Li, Lan Liu
Year
2016
Journal
Phytochemistry Letters
Abstract
Four new azaphilones, peniazaphilones A–D (1–4), together with four analogues (5–8), were isolated from the alga-derived fungus Penicillium sp. ZJ-27. The structures of 1–8were elucidated by 1D and 2D NMR analysis. The absolute configurations of 1–4 were determined by electronic circular dichroism (ECD). The isolated compounds were evaluated for cytotoxic activity against two tumor cell lines and antibacterial activities against twelve aquatic pathogenic bacteria.
Instrument
J-810
Keywords
Circular dichroism, Absolute configuration, Pharmaceutical