Title
Cytotoxic dimeric xanthanolides from fruits of Xanthium chinense
Author
Jing Qu, Shidong Deng, Li Li, Yunbao Liu, Yong Li, Shuanggang Ma, Xiaoguang Chen, Shishan Yu
Year
2016
Journal
Phytochemistry
Abstract
Nine dimeric xanthanolides, pungiolides F–N, and five known analogues, pungiolides A–E, were isolated from fruits of Xanthium chinense. Their structures were elucidated through spectroscopic and electronic circular dichroism (ECD) analyses. Pungiolide F is a xanthanolide dimer with an acyclic linkage. Five of the dimers, pungiolides H, L, A, C and E, exhibited moderate cytotoxicities with IC50 values in the range of 0.90–6.84 μM using taxol as the positive control, which had, by comparison, IC50 values in the range of 0.00118–0.0675 μM. These findings enrich the structural diversity of dimeric sesquiterpene lactones.
Instrument
J-815
Keywords
Circular dichroism, Absolute configuration, Natural products