Title
Flavonoid dimers from the total phenolic extract of Chinese dragon’s blood, the red resin of Dracaena cochinchinensis
Author
Dao-Ran Pang, Xiao-Qin Su, Zhi-Xiang Zhu, Jing Sun, Yue-Ting Li, Yue-Lin Song, Yun-Fang Zhao, Peng-Fei Tu, Jiao Zheng, Jun Li
Year
2016
Journal
Fitoterapia
Abstract
Eight new flavonoid dimers, named cochinchinenins I–M (1–5), including three pairs of enantiomers (1a/1b–3a/3b) and two optically pure flavonoid dimers (4–5), along with a known analogue (6), were isolated from total phenolic extract of the red resin of Dracaena cochinchinensis (Chinese dragon's blood). The planar structures of 1–5 were elucidated by extensive spectroscopic analysis including HRESIMS and 1D/2D NMR. Their absolute configurations were determined on the basis of experimental and calculated electronic circular dichroism (ECD) data. Compounds 4 and 5 exhibited significant inhibition of nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells with IC50 value of 4.9 ± 0.4 and 5.4 ± 0.6 μM, respectively.
Instrument
J-810
Keywords
Circular dichroism, Absolute configuration, Medicinal