New picrotoxane terpenoids, austrobuxusin A-D, from the Australian endemic plant Austrobuxus swanii

By Ozlem Demirkiran, Marc Campitelli, Chao Wang, Yunjiang Feng

July 28, 2017

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  • Industry

Title

New picrotoxane terpenoids, austrobuxusin A-D, from the Australian endemic plant Austrobuxus swanii

Author

Ozlem Demirkiran, Marc Campitelli, Chao Wang, Yunjiang Feng

Year

2016

Journal

Tetrahedron

Abstract

Four new picrotoxane terpenoids, austrobuxusin A–D (1–4), were isolated from the Australian endemic plant Austrobuxus swanii. Their structures were fully characterized by 1D- and 2D-NMR and MS data. The relative configurations of compounds (1–4) were assigned by phase-sensitive ROESY experiment. The absolute configuration of austrobuxusin A (1) was determined by the comparison of experimental and DFT-calculated CD spectra. This is the first report of picrotoxane terpenoids from the Australian plant Austrobuxus swanii.

Full Article

http://www.sciencedirect.com/science/article/pii/S0040402016311206

Instrument

J-715

Keywords

Circular dichroism, Absolute configuration, Natural products, Pharmaceutical