Title
A novel caged-glutamine derivative as a tool to control the assembly of glutamine-containing amyloidogenic peptides
Author
Loay Awad, Nino Jejelava, Ritwik Burai, Hilal A. Lashuel
Year
2016
Journal
ChemBioChem
Abstract
Here, we present the design, synthesis and characterization of a novel photocaged glutamine derivative on the side-chain of glutamine and describe its use in enhancing peptide stability and solubility. Our results demonstrate that this approach can be used to develop molecular switches to control the folding and β-sheet formation of amyloidogenic peptides.
Instrument
J-815
Keywords
Circular dichroism, Secondary structure, Biochemistry