New Benzophenones and Xanthones from Cratoxylum sumatranum ssp. neriifolium and Their Antibacterial and Antioxidant Activities

By Cholpisut Tantapakul, Wisanu Maneerat, Tawanun Sripisut, Thunwadee Ritthiwigrom, Raymond J. Andersen, Ping Cheng, Sarot Cheenpracha, Achara Raksat, Surat Laphookhieo

July 28, 2017

  • Year

  • Technique

  • Industry

Title

New Benzophenones and Xanthones from Cratoxylum sumatranum ssp. neriifolium and Their Antibacterial and Antioxidant Activities

Author

Cholpisut Tantapakul, Wisanu Maneerat, Tawanun Sripisut, Thunwadee Ritthiwigrom, Raymond J. Andersen, Ping Cheng, Sarot Cheenpracha, Achara Raksat, Surat Laphookhieo

Year

2016

Journal

Journal of Agricultural and Food Chemistry

Abstract

Two new benzophenones (1 and 2) and four new xanthones (4–6 and 17) together with 24 known compounds (3, 7–16 and 18–30) were isolated from the roots and twigs of Cratoxylum sumatranum ssp. neriifolium. Their structures were elucidated by spectroscopic methods. Compounds 5 and 26 showed antibacterial activity against Micrococcus luteus, Bacillus cereus, and Staphylococcus epidermis with MIC values ranging from 4–8 µg/mL, whereas compounds 7, 20, and 26 displayed selective antibacterial activities against Staph. aureus (8 µg/mL), Salmonella typhimurium (4 µg/mL) and Pseudomonas aeruginosa (4 µg/mL), respectively. The radical scavenging effects of some isolated compounds were investigated. Compounds 11 and 21 exhibited potent activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) with IC50 values of 7.0 ± 1.0 and 6.0 ± 0.2 µM, respectively.

Full Article

http://pubs.acs.org/doi/abs/10.1021/acs.jafc.6b03643

Instrument

J-815

Keywords

Circular dichroism, Stereochemistry, Agricultural and environmental, Natural products