Title
Sesquiterpenoid and C14-polyacetylene glycosides from the rhizomes of Atractylodes lancea
Author
Kuo Xu, Zi-Ming Feng, Jian-Shuang Jiang, Ya-Nan Yang, Pei-Cheng Zhang
Year
2016
Journal
Chinese Chemical Letters
Abstract
Four new glycosides including a eudesmane-type sesquiterpenoid (1), a guaiane-type sesquiterpenoid (2), and two C14-polyacetylenes (3, 4) were isolated from the rhizomes of Atractylodes lancea. Their structures were elucidated by means of spectroscopic and spectrometric analyses (UV, IR, 1D and 2D NMR, and HR-ESIMS). The absolute configurations of their aglycones were established based on the experimental and calculated electronic circular dichroism (ECD), whereas those of monosaccharide moieties were determined by the GC method after chiral derivatization. Compound 4showed weak anti-inflammatory effects on the LPS-induced NO production in microglia BV2 cells at a concentration of 10 μmol L−1.
Instrument
J-815
Keywords
Circular dichroism, Absolute configuration, Natural product,s Medicinal