Title
Chiral separation and absolute configurations of two pairs of racemic polyprenylated benzophenones from Hypericum sampsonii
Author
Wen-Jing Tian, Yu-Qin Qiu, Hai-Feng Chen, Xiao-Jie Jin, Xiao-Jun Yao, Yi Dai, Xin-Sheng Yao
Year
2016
Journal
Fitoterapia
Abstract
(±) Sampsonins A–B (1–2), two pairs of racemic polyprenylated benzophenones, were isolated from the aerial parts of Hypericum sampsonii and successfully separated by chiral HPLC column. Their structures were elucidated by spectroscopic analyses, X-ray diffraction analysis, and quantum chemical calculation of ECD method. Besides, the plausible biogenetic pathways of 1–2 were proposed, and all of them were evaluated for RXRα transcriptional-inhibitory activities and cytotoxicity against HeLa cells.
Instrument
J-810
Keywords
Circular dichroism, Absolute configuration, Stereochemistry, Pharmaceutical, Medicinal