Cytotoxic germacrane-type sesquiterpene lactones from the whole plant of Inula cappa

By Jie-Wei Wu, Chun-Ping Tang, Yao-Yao Cai, Chang-Qiang Ke, Li-Gen Lin, Sheng Yao, Yang Ye

July 28, 2017

  • Year

  • Technique

  • Industry

Title

Cytotoxic germacrane-type sesquiterpene lactones from the whole plant of Inula cappa

Author

Jie-Wei Wu, Chun-Ping Tang, Yao-Yao Cai, Chang-Qiang Ke, Li-Gen Lin, Sheng Yao, Yang Ye

Year

2016

Journal

Chinese Chemical Letters

Abstract

Phytochemical investigation on the whole plant of Inula cappa led to the isolation of two new germacrane-type sesquiterpene lactones, ineupatolides D and E (1 and 2), together with three known analogs. The structures of the new compounds were established by extensive analysis of 1D and 2D NMR spectra, as well as MS data. Their absolute configurations were determined by CD spectra. All compounds showed moderate inhibitory effects on A431, A549, BGC-823, HL-60, HT-29, and MCF-7 cancer cell lines with IC50 values ranging from 2.1 to 36.3 μM.

Full Article

http://www.sciencedirect.com/science/article/pii/S1001841716303989

Instrument

J-810

Keywords

Circular dichroism, Absolute configuration, Medicinal