Title
Relative strand orientation in a DNA duplex controls the nuclearity of a metal-mediated base pair
Author
Soham Mandal, Marian Hebenbrock, Jens Müller
Year
2016
Journal
Chemistry A European Journal
Abstract
1,N6-Ethenoadenine (eA) and cytosine (C) are able to form two different metal-mediated base pairs. When the glycosidic bonds are arranged in a cisoid manner (i.e. in antiparallel-stranded DNA), the eA:C mispair binds one Ag(I) ion, leading to a mononuclear eA-Ag(I)-C base pair that contains a synergistic hydrogen bond. In contrast, a transoid orientation of the glycosidic bonds (as found in parallel-stranded DNA) results in the formation of a dinuclear metal-mediated base pair eA-Ag(I)2-C.
Instrument
J-815
Keywords
Circular dichroism, DNA structure, Ligand binding, Biochemistry