Title
Organocatalytic enantioselective Michael reaction of 1,3-dicarbonyls with α-substituted β-nitroacrylates
Author
Hsuan-Hao Chang, Kai-Di Chu, Ming-Hsi Chiang, Jeng-Liang Han
Year
2016
Journal
Tetrahedron
Abstract
An efficient asymmetric Michael reaction of 1,3-dicarbonyl compounds with α-Substituted-β-Nitroacrylates has been developed by using a cinchona-thiourea bifunctional organocatalyst in high yields and enantioselectivies. One of adducts could be transformed into a chiral β-nitroester bearing an isoxazole skeleton and an all-carbon quaternary chiral center.
Instrument
J-815
Keywords
Circular dichroism, Absolute configuration,