Nine new compounds from the root bark of Lycium chinense and their α-glucosidase inhibitory activity

By Ya-Nan Yang, Ya-Wen An, Zhi-Lai Zhan, Jing Xie, Jian-Shuang Jiang, Zi-Ming Feng, Fei Ye, Pei-Cheng Zhang

July 28, 2017

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Title

Nine new compounds from the root bark of Lycium chinense and their α-glucosidase inhibitory activity

Author

Ya-Nan Yang, Ya-Wen An, Zhi-Lai Zhan, Jing Xie, Jian-Shuang Jiang, Zi-Ming Feng, Fei Ye, Pei-Cheng Zhang

Year

2016

Journal

RSC Advances

Abstract

Lycium chinense Mill. is a deciduous shrub in the Solanaceae family that is known for its fruits (Lycii fructus) and root bark (Lycii cortex). In our ongoing search for α-glucosidase inhibitors from the root bark of L. chinense, lyciumflavane A, one new flavane with an unusual benzofuran unit, one new amide possessing a naphthalene skeleton, one new sesquiterpene, three new lignan glucosides, and three new phenolic glucosides were isolated along with eight known compounds. Their structures were elucidated using NMR, HRESIMS, UV, ECD, and IR spectroscopic data. Their α-glucosidase inhibitory activity was screened using acarbose as a positive control (IC50 = 385 μM). Compound 1 showed strong inhibitory activity against α-glucosidase (IC50 = 20.89 μM).

Full Article

http://pubs.rsc.org/en/content/articlehtml/2017/ra/c6ra24751b

Instrument

J-815

Keywords

Circular dichroism, Absolute configuration, Natural products, Medicinal