Title
Synthesis, Characterization and Immunological Evaluation of Self-Adjuvanting Group A Streptococcal Vaccine Candidates Bearing Various Lipidic Adjuvanting Moieties
Author
Vincent Fagan, Waleed M. Hussein, Mei Su, Ashwini K. Gidda, Michael R. Batzloff, Michael F. Good, Istvan Toth, Pavla Simerska
Year
2017
Journal
ChemBioChem
Abstract
Four group A streptococcal glyco-lipopeptide vaccine candidates were prepared and characterized, each possessing different lipidic adjuvanting moieties. The immunogenicity of the compounds was evaluated by macrophage and dendritic cell uptake studies and by in vivo quantification of systemic IgG antibody using ELISA. Three of the four vaccine candidates showed a significant induction of IgG response compared to a negative control.
Instrument
J-710
Keywords
Circular dichroism, Secondary structure, Biochemistry