Title
The Coordination Abilities of Three Novel Analogues of Saliva Peptides: The Influence of Structural Modification on the Copper Binding
Author
Aleksandra Kotynia, Edward Krzyżak, Elżbieta Kamysz, Małgorzata Sobocińska, Justyna Brasuń
Year
2017
Journal
International Journal of Peptide Research and Therapeutics
Abstract
Three novel analogues of salivary peptides as sialorphin (QHNPR) and opiorphin (QRFSR) were synthesized by the solid-phase method. The sequences of these ligands were following: AHNPR, QANPR and QRFPR. The aim of our work was investigation in what way some structural modifications may impact on coordination abilities of studied peptides. In this work we presented the interaction of pentapeptides with copper(II) ions in wide range of pH. To determine the coordination model of ligands there were carried out several studies by spectroscopy (UV–Vis, CD) methods and potentiometric measurements.
Instrument
J-1500
Keywords
Circular dichroism, Magnetic circular dichroism, Coordination chemistry, Biochemistry