Sesquiterpene dimers from the roots of Chloranthus holostegius with moderate anti-inflammatory activity

By Chuan-Pu Shen, Jian-Guang Luo, , Ming-Hua Yang, Ling-Yi Kong

July 28, 2017

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Title

Sesquiterpene dimers from the roots of Chloranthus holostegius with moderate anti-inflammatory activity

Author

Chuan-Pu Shen, Jian-Guang Luo, , Ming-Hua Yang, Ling-Yi Kong

Year

2017

Journal

Phytochemistry

Abstract

Eight lindenane dimers, chololactones A-H, along with two known compounds, were isolated from the roots of Chloranthus holostegius. Their structures were elucidated using 1D/2D NMR and HRESIMS, and their absolute configurations were determined using the ECD exciton chirality method. All isolates were tested for inhibitory effects on the NO production of the liposaccharide (LPS)-induced RAW 264.7 macrophages, and showed moderate activity with IC50 values at 3.5–35.4 μM.

Full Article

http://www.sciencedirect.com/science/article/pii/S0031942217300523

Instrument

J-810

Keywords

Circular dichroism, Absolute configuration, Natural products, Medicinal