Two new secolignans with in vitro anti-inflammatory activities from Urtica fissa rhizomes

By Xiaoru Feng, Mengyue Wang, Jun Cheng, Xiaobo Li

July 28, 2017

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Title

Two new secolignans with in vitro anti-inflammatory activities from Urtica fissa rhizomes

Author

Xiaoru Feng, Mengyue Wang, Jun Cheng, Xiaobo Li

Year

2017

Journal

Journal of Natural Medicines

Abstract

Two new secolignans, urticin A (1) and urticin B (2), were isolated from the ethanol extract of Urtica fissa rhizomes. Their structures were elucidated on the basis of extensive spectroscopic evidence (UV, IR, HR-ESI–MS, and NMR). Urticin A and urticin B possessed in vitro anti-inflammatory activities, which significantly inhibited the TNF-α and NO release induced by LPS in RAW 264.7 cells.

Full Article

https://link.springer.com/article/10.1007/s11418-017-1078-5

Instrument

J-815

Keywords

Circular dichroism, Absolute configuration, Natural products, Medicinal