Title
Five new koumine-type alkaloids from the roots of Gelsemium elegans
Author
Wei Zhang, Sheng-Yuan Zhang, Gui-Yang Wang, Ni-Ping Li, Min-Feng Chen, Ji-Hong Gu, Dong-Mei Zhang, Lei Wang, Wen-Cai Ye
Year
2017
Journal
Fitoterapia
Abstract
Five new koumine-type alkaloids (1–5) along with six known ones were isolated from the roots of Gelsemium elegans. Their structures with absolute configurations were elucidated on the basis of NMR spectroscopy and electronic circular dichroism spectral analyses. The inhibitory effects of compounds 1–11 on the viability of three tumor cell lines (A-649, HepG2, and HuH7) were evaluated by the MTT assay.
Instrument
J-810
Keywords
Circular dichroism, Absolute configuration, Natural products, Medicinal