Title
Six new sesquiterpenoids from Nardostachys chinensis Batal
Author
Xiu-yu Shen, Yang Yu, Guo-dong Chen, Hua Zhou, Jin-fang Luo, Yi-han Zuo, Xin-sheng Yao, Yi Dai
Year
2017
Journal
Fitoterapia
Abstract
Six new sesquiterpenoids, namely nardosinanones J-N and nardoaristolones C, were isolated from the rhizomes and roots of Nardostachys chinensis Batal. Their structures were determined by interpretation of spectroscopic data (HR-ESI-MS, 1D and 2D NMR). A combination of X-ray crystal diffraction, ECD calculation, and Mosher ester methods was employed to determine the absolute configuration of the isolated compounds. Compounds 1–2, 4–6 were evaluated anti-inflammatory activities in LPS-stimulated RAW264.7 macrophages. The results showed that compound 5 obviously inhibited LPS-induced iNOS and COX-2 protein expression compared to single LPS stimulation, which indicated the potential effect to medicate anti-inflammatory.
Instrument
J-810
Keywords
Circular dichroism, Absolute configuration, Natural products, Medicinal