Title
Flavanonol glucosides from the aerial parts of Agrimonia pilosa Ledeb. and their acetylcholinesterase inhibitory effects
Author
U. Min Seo, Duc Hung Nguyen, Bing Tian Zhao, Byung Sun Min, Mi Hee Woo
Year
2017
Journal
Carbohydrate Research
Abstract
Two new flavanonol glucoside isomers, (2R,3S)-dihydrokaempferol 3-O-β-D-glucoside (1) and (2S,3R)-dihydrokaempferol 3-O-β-D-glucoside (2), were isolated from the aerial parts of Agrimonia pilosa Ledeb., along with eight known flavanonol glucosides (3–10). Their structures were determined on the basis of spectroscopic analysis. In addition, these compounds were evaluated to determine their acetylcholinesterase inhibitory activities. The results indicated that these compounds have moderate inhibitory effects, with IC50 values ranging from 76.59 ± 1.16 to 97.53 ± 1.64 μM, except compounds 1 and 4 were inactive.
Instrument
J-715
Keywords
Circular dichroism, Stereochemistry, Natural products, Pharmaceutical