Title
Indole alkaloid sulfonic acids from an aqueous extract of Isatis indigotica roots and their antiviral activity
Author
Lingjie Meng, Qinglan Guo, Yufeng Liu, Minghua Chen, Yuhuan Li, Jiandong Jiang, Jiangong Shi
Year
2017
Journal
Acta Pharmaceutica Sinica B
Abstract
Six new indole alkaloid sulfonic acids (1–6), together with two analogues (7 and 8) that were previously reported as synthetic products, were isolated from an aqueous extract of the Isatis indigotica root. Their structures including the absolute configurations were determined by spectroscopic data analysis, combined with enzyme hydrolysis and comparison of experimental circular dichroism and calculated electronic circular dichroism spectra. In the preliminary assay, compounds 2 and 4 showed antiviral activity against Coxsackie virus B3 and influenza virus A/Hanfang/359/95 (H3N2), respectively.
Instrument
J-815
Keywords
Circular dichroism, Stereochemistry, Natural products, Medicinal