Nine compounds from the root bark of Lycium chinense and their anti-inflammatory activitieslammatory activitiesretain–>

By Yanan Yang, Yawen An, Wei Wang, Ning Du, Jinghua Zhang, Ziming Feng, Jianshuang Jiang, Peicheng Zhang

July 28, 2017

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Title

Nine compounds from the root bark of Lycium chinense and their anti-inflammatory activitieslammatory activitiesretain–>

Author

Yanan Yang, Yawen An, Wei Wang, Ning Du, Jinghua Zhang, Ziming Feng, Jianshuang Jiang, Peicheng Zhang

Year

2017

Journal

Acta Pharmaceutica Sinica B

Abstract

Two new compounds, named lyciumlignan D (1) and lyciumphenyl propanoid A (2), along with seven known compounds, were isolated from the root bark of Lycium chinense. Their structures were elucidated using spectroscopic data (UV, IR, HR-ESI-MS, 1D and 2D NMR, CD), as well as by comparison with those of the literature. Compounds 3single bond9 were isolated from this genus for the first time. In the in vitro assay, compounds 3, 6, and 7 exhibited stronger anti-inflammatory effects than the positive control curcumin at a concentration of 10 μmol/L.

Full Article

http://www.sciencedirect.com/science/article/pii/S221138351730076X

Instrument

J-815

Keywords

Circular dichroism, Stereochemistry, Natural products, Pharmaceutical