Title
Bioactive composition of Reevesia formosana root and stem with cytotoxic activity potential†
Author
Hsun-Shuo Chang, Chu-Hung Lin, Pei-Yu Hsiao, Hung-Ti Peng, Shiow-Ju Lee, Ming-Jen Cheng, Ih-Sheng Chen
Year
2017
Journal
RSC Advances
Abstract
Six new compounds including three lignanoids: reevesiacoumarin (1), reevesic acid (2), and reevesilignan (3), and three terpenoids: reevesiterpenol A (4), reevesiterpenol B (5), and 3α,27-di-O-trans-caffeoylbetulinic acid (6), along with 40 known compounds were isolated from the root and stem of Reevesia formosana (Sterculiaceae). The structures of 1–6 were determined by spectroscopic techniques. Bioassays for the cytotoxicities of MCF-7, NCI–H460, and HepG2 cancer cell lines led to finding three cardenolides: strophanthojavoside (31) and ascleposide (32) with IC50 < 1 μM and strophalloside (33) displayed selective cytotoxicity to NCI–H460 with IC50 0.62 ± 0.06 μM as well. 3α,27-Di-O-trans-caffeoylbetulinic acid (6) and secoisolariciresinol (13) also showed weak but selective cytotoxicity to NCI–H460 and HepG2 cancer cell lines, respectively.
Instrument
J-810
Keywords
Circular dichroism, Absolute configuration, Natural products, Pharmaceutical