Title
Isolation and Characterization of Sesquiterpenoids from Cassia Buds and Their Antimicrobial Activities
Author
Yindengzhi Guoruoluo, Haofeng Zhou, Junfei Zhou, Haiqing Zhao, Haji Akber Aisa, Guangmin Yao
Year
2017
Journal
Journal of Agricultural and Food Chemistry
Abstract
Cassia buds, the immature fruits of Cinnamomum cassia (Lauraceae), are widely consumed as a food spice, dietary supplements, flavoring agents, and preservatives. In this study, cassia buds were phytochemically investigated for the first time, leading to the isolation of 2 new sesquiterpenoids (1 and 2) and 10 known sesquiterpenoids (3–12). Their structures were determined by spectrometric and spectroscopic analyses, including nuclear magnetic resonance, high-resolution electrospray ionization mass spectrometry, and circular dichroism. Cinnamosim A (1) represents the ninth example of the rare cyperane-type sesquiterpenoids. All of the compounds (1–12) isolated from cassia buds were evaluated for antimicrobial activities, with compounds 1–3, 5–8, 11, and 12 exhibiting strong antimicrobial activities against Candida albicans and compounds 6, 7, and 11 showing moderate antibacterial activities against Escherichia coli and Staphylococcus aureus. The present investigation indicated that sesquiterpenoids from cassia buds might be used as potential antimicrobial agents to preserve food.
Full Article
Instrument
J-810
Keywords
Circular dichroism, Absolute configuration, Pharmaceutical, Agricultural and environmental