Title
Smart Poly(imidazoyl-l-lysine): Synthesis and Reversible Helix-to-Coil Transition at Neutral pH
Author
Estefania Piedra-Arroni, Fatma Makni, Laura Severac, Jean-Luc Stigliani, Geneviève Pratviel, Colin Bonduelle
Year
2017
Journal
Polymers
Abstract
Polypeptide polymers can adopt natural protein secondary structures such as α-helices or β-sheets, and this unique feature is at the origin of some intriguing physico–chemical properties. In this work, we present how side chain imidazoylation of a poly(l-lysine) scaffold affords the preparation of poly(histidine) counterparts exhibiting α-helix conformation. This structuring behavior is reversible and can be controlled by means of pH and or temperature changes.
Full Article
Instrument
J-815
Keywords
Circular dichroism, Secondary structure, Chemical stability, Polymers, Biochemistry