Title
Phytochemical characterization and biological activity of secondary metabolites from three Limonium species
Author
Anastassiya V. Gadetskaya, Shaymaa M. Mohamed, Amer H. Tarawneh, Nesma M. Mohamed, Guoyi Ma, Boris N. Ponomarev, Galiya E. Zhusupova, Charles L. Cantrell, Stephen J. Cutler, Samir A. Ross
Year
2017
Journal
Medicinal Chemistry Research
Abstract
The comparative phytochemical constituents of three Limonium species Limonium myrianthum, Limonium leptophyllum, and Limonium gmelinii afforded a new compound (2R,3S)-2,3,4-trihydroxy-2-methylbutyl gallate (1) and twenty known compounds (2–21). Each species displayed different profiles in their phytochemical constituents. The isolated compounds (1–21) were evaluated for antifungal, antimalarial, and antitrypanosomal activities. Compound 1 showed good activity against chloroquine-resistant and chloroquine-sensitive strains of malaria, while compound 5 displayed moderate antimalarial activity. Compound 14showed a significant activity against Trypanosoma brucei.
Instrument
J-715
Keywords
Circular dichroism, Absolute configuration, Pharmaceutical, Natural products