Title
New phloroglucinol derivatives from the whole plant of Hypericum uralum
Author
Xiaoqing Li, Yun Li, Jianguang Luo, Zhongbo Zhou, Guimin Xue, Lingyi Kong
Year
2017
Journal
Fitoterapia
Abstract
Seven new phloroglucinol derivatives, uraliones L-R (1–7), were isolated from the whole plant of Hypericum urialum. The structures of new compounds were unambiguously elucidated by comprehensive spectroscopic analysis, and the absolute configurations of the vic-diol groups were determined by Mo2(OAc)4-induced electronic circular dichroism experiments. Their capability to reversal the multidrug resistance in doxorubicin-induced resistant MCF-7/DOX sublines showed that compounds 1, 5, 6, 7 exerted a potential effect of doxorubicin susceptibility.
Instrument
J-810
Keywords
Circular dichroism, Absolute configuration, Natural products