Title
Metabolites from the Plant Endophytic Fungus Aspergillus sp. CPCC 400735 and Their Anti-HIV Activities
Author
Xu Pang, Jian-Yuan Zhao, Xiao-Mei Fang, Tao Zhang, De-Wu Zhang , Hong-Yu Liu, Jing Su, Shan Cen, Li-Yan Yu
Year
2017
Journal
Journal of Natural Products
Abstract
Thirty-three metabolites including five phenalenone derivatives (1–5), seven cytochalasins (6–12), thirteen butenolides (13–25), and eight phenyl derivatives (26–33) were isolated from Aspergillussp. CPCC 400735 cultured on rice. The structures of all compounds were elucidated by NMR, MS, and CD experiments, of which 1–5 (asperphenalenones A–E), 6 (aspochalasin R), and 13(aspulvinone R) were identified as new compounds. Specifically, asperphenalenones A–E (1–5) represent an unusual structure composed of a linear diterpene derivative linked to a phenalenone derivative via a C–C bond. Compounds 1, 4, 10, and 26 exhibited anti-HIV activity with IC50 values of 4.5, 2.4, 9.2, and 6.6 μM, respectively (lamivudine 0.1 μM; efavirenz, 0.4 × 10–3 μM).
Instrument
J-815
Keywords
Circular dichroism, Absolute configuration, Natural products