Title
New diterpenoids from the marine sponge Dactylospongia elegans
Author
Hao-Bing Yu, Bin-Bin Gu, Shu-Ping Wang, Chun-Wei Cheng, Fan Yang, Hou-Wen Lin
Year
2017
Journal
Tetrahedron
Abstract
Eleganstone A (1), a rare diterpene possessing a 5/6/4/5 fused tetracyclic ring skeleton, along with its probable biogenetic precursor (2), one new dolabellane diterpene (3), and one known dolabellane diterpene (4), have been isolated from the marine sponge Dactylospongia elegans. As a pair of Z/E isomers, 2 can convert into 4by the light-induced isomerization. Structure elucidations of all compounds were performed by spectroscopic analysis, ECD calculations, and comparison with the literature. These compounds were tested for their antibacterial and cytotoxic activities. Compounds 1–4 exhibited weak antibacterial activity against Escherichisa coli, Bacillus subtilis, and Staphylococcus aureus with MIC values of 32–64 μg/mL.
Instrument
J-715
Keywords
Circular dichroism, Absolute configuration, Natural products