Title
Di(1-naphthyl) methanol ester of carboxylic acids for absolute stereochemical determination
Author
Jun Zhang, Wei Sheng, Hadi Gholami, Tatsuo Nehira, Babak Borhan
Year
2018
Journal
Chirality
Abstract
The absolute stereochemistry of chiral carboxylic acids is determined as a di(1-naphthyl)methanol ester derivative. Computational scoring of conformations favoring either P or M helicity of the naphthyl groups, capable of exciton-coupled circular dichroic coupling, leads to a predicted stereochemistry for the derivatized carboxylic acids.
Instrument
J-810
Keywords
Circular dichroism, Absolute configuration