Title
Approach to Comparing the Functional Group Tolerance of Reactions
Author
Tobias Gensch, Michael Teders, Frank Glorius
Year
2017
Journal
The Journal of Organic Chemistry
Abstract
Herein, we describe an approach to quantifying and comparing functional group (FG) tolerance of synthetic reactions. Additive-based reaction screening is utilized as a tool for the objective comparison of reaction conditions as demonstrated in four case studies. This contributes to an understanding of factors limiting a reaction’s FG tolerance and the identification of truly mild reactions.
Full Article
Instrument
FP-8300
Keywords
Fluorescence, Luminescence, Organic chemistry