Title
Antiviral Triketone‐Phloroglucinol‐Monoterpene Adducts from Callistemon rigidus
Author
Jia-Qing Cao, Yan Wu, Yuan-Lin Zhong, Ni-Ping Li, Mu Chen, Man-Mei Li, Wen-Cai Ye, Lei Wang
Year
2018
Journal
Chemistry & Biodiversity
Abstract
Callistrilones F–K (1–6), six new triketone-phloroglucinol-monoterpene hybrids were isolated from the twigs and leaves of Callistemon rigidus. Their structures with absolute configurations were established by a combination analysis of NMR spectra, X-ray diffraction and electronic circular dichroism (ECD) calculations. Compounds 3 and 4 exhibited moderate inhibitory activities against herpes simplex virus (HSV-1) with IC50 values of 10.00 ± 2.50 and 12.50 ± 1.30 µM, respectively.
Instrument
J-810
Keywords
Circular dichroism, Absolute configuration, Natural products, Medicinal, Pharmaceutical