Title
From self-assembled peptide-ynes to peptide polyacetylenes and polydiacetylenes
Author
Giulia Marafon, Maria Angela Motta, Claudio Toniolo, Alessandro Moretto
Year
2018
Journal
Peptide Science
Abstract
A set of four organogelators from an α-amino acid derivative to a tetrapeptide, covalently linked to an acetylenic moiety, was studied in terms of polymerization efficiencies to afford peptide polyacetylenes and polydiacetylenes. Peptides were designed to improve the organogelator behavior via formation of intermolecular H-bonding-mediated β-sheet networks as a function of their main-chain length. The polymerization experiments were run under appropriate conditions for the various monomers with the aim at elucidating how the monomer self-assembly process might influence polymer formation. Starting compounds and their corresponding polymers were characterized by a variety of spectroscopic and microscopic techniques.
Instrument
J-715
Keywords
Circular dichroism, Secondary structure, Chemical stability, Aggregation, Biochemistry