Minor Nortriterpenoids from the Twigs and Leaves of Rhododendron latoucheae

By Fei Liu, Ya-Nan Wang, Yong Li, Shuang-Gang Ma, Jing Qu, Yun-Bao Liu, Chang-Shan Niu, Zhong-Hai Tang, Yu-Huan Li, Li Li, Shi-Shan Yu

October 11, 2018

  • Year

  • Technique

  • Industry

Title

Minor Nortriterpenoids from the Twigs and Leaves of Rhododendron latoucheae

Author

Fei Liu, Ya-Nan Wang, Yong Li, Shuang-Gang Ma, Jing Qu, Yun-Bao Liu, Chang-Shan Niu, Zhong-Hai Tang, Yu-Huan Li, Li Li, Shi-Shan Yu

Year

2018

Journal

Journal of Natural Products

Abstract

A hyphenated NMR technique (analytical HPLC with a DAD connected to MS, SPE, and NMR) has proven effective for the full structural analysis and identification of minor natural products in complex mixtures. Application of this hyphenated technique to the CH2Cl2- soluble fraction of Rhododendron latoucheae led to the identification of 15 new minor ursane-type 28-nortriterpenoids (1−15). Compounds 1 and 12 inhibited HSV-1 with IC50 values of 6.4 and 0.4 μM, respectively.

Full Article

https://pubs.acs.org/doi/abs/10.1021/acs.jnatprod.7b01074

Instrument

J-815

Keywords

Circular dichroism, Absolute configuration, Cotton effect, Natural products, Medicinal