Chirality sensing of bioactive compounds with amino alcohol unit via circular dichroism

November 2, 2018

Title

Chirality sensing of bioactive compounds with amino alcohol unit via circular dichroism

Author

Marcin Górecki, Grażyna Groszek, Jadwiga Frelek

Year

2017

Journal

Chirality

Abstract

The aim of the present work was to test various chiroptical techniques, including in particular the in situ dirhodium methodology, to assign the absolute configuration of 1,2‐ and 1,3‐amino alcohols. As models, we selected mainly compounds that have both an additional strongly absorbing and interfering chromophoric system and application in medicinal chemistry. Determination of the absolute configuration (AC) of the tested molecules such as cinchona alkaloids, Tamiflu, and others was carried out using a combination of electronic and vibrational circular dichroism (ECD, VCD) spectroscopy. It has been demonstrated that both 1,2‐ and 1,3‐aminol moieties are subject to the same sector rule correlating stereostructure of formed Rh2‐complex with chiroptical properties, and that the changes in the position of the stereogenic center do not affect its proper use.

Instrument

FVS-6000

Keywords

Vibrational circular dichroism, mino alcohols 1,3‐amino alcohols absolute configuration auxiliary chromophore circular dichroism dirhodium tetraacetate