Highly selective binding behavior of (diethylamino)coumarin-modified β-cyclodextrin with bile acids

By Tetsuo Kuwabara, Yuta Hosokawa, Jinyang Hu, Takeshi Ide

February 28, 2019

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Title

Highly selective binding behavior of (diethylamino)coumarin-modified β-cyclodextrin with bile acids

Author

Tetsuo Kuwabara, Yuta Hosokawa, Jinyang Hu, Takeshi Ide

Year

2018

Journal

Journal of Inclusion Phenomena and Macrocyclic Chemistry

Abstract

A (diethylamino)coumarin-modified β-cyclodextrin (1) increased its fluorescence intensity upon guest binding in an aqueous media, and this phenomenon was used to detect organic compounds, specifically bile acids. The modified β-cyclodextrin chemosensor in this study exhibited remarkable molecular recognition, and particularly high selectivity toward certain bile acids, including lithcholic, chenodeoxycholic, and ursodeoxycholic acid.

Full Article

https://link.springer.com/article/10.1007/s10847-018-0845-6

Instrument

J-820, FP-6300

Keywords

Circular dichroism, Induced circular dichroism, Chemical stability, Materials, Fluorescence, Ligand binding, Sensors