Title
Caryophyllene sesquiterpenes, chromones and 10-membered macrolides from the marine-derived fungus Pseudopestalotiopsis sp. PSU-AMF45
Author
Haryadi N. Putra, Vatcharin Rukachaisirikul, Saowanit Saithong, Souwalak Phongpaichit, Sita Preedanon, Jariya Sakayaroj, Sarinya Hadsadee, Siriporn Jungsuttiwong
Year
2019
Journal
Tetrahedron
Abstract
Three new caryophyllene sesquiterpenes, pestalotiopsins I–K, one new chromone, pseudopestalone, and one new 10-membered macrolide, decarestrictine Q, were isolated from the fermentation broth of the marine-derived fungus Pseudopestalotiopsis sp. PSU-AMF45 along with twelve known compounds. Their structures were identified by spectroscopic data including 1D and 2D NMR. The absolute configuration of pestalotiopsin I was assigned based on single-crystal X-ray diffraction crystallography whereas that of the secondary alcohol moiety in pestalotiopsin J was established by Mosher's method. For pseudopestalone, the absolute configuration was determined by ECD spectrum associated with TD-DFT calculation. The antimicrobial activity of the isolated compounds was evaluated.
Instrument
J-815
Keywords
Circular dichroism, Absolute configuration, Natural products, Medicinal