Title
Seven new flavonoid glycosides from the roots of Glycyrrhiza uralensis and their biological activities
Author
Ya-Nan Yang, Yuan-Yuan Liu, Zi-Ming Feng, Jian-Shuang Jiang, Pei-Cheng Zhang
Year
2019
Journal
Carbohydrate Research
Abstract
As part of our ongoing investigation of the bioactive constituents from the roots of Glycyrrhiza uralensis Fisch., seven new flavonoid glycosides (1–7) were obtained along with 19 known compounds (8–26). All of the isolates possessed one or more sugar moieties. Their structures, as well as the absolute configurations, were elucidated on the basis of spectroscopic data (UV, IR, HRESIMS, 1D and 2D NMR, and CD). In the in vitro assay, compounds 3 and 7 showed moderate antioxidant activities at a concentration of 0.1 μM; compound 2 showed hepatoprotective activity at a concentration of 10 μM.
Instrument
J-815, V-650
Keywords
Circular dichroism, Stereochemistry, Absolute configuration, Absorption, Quantitation, Natural products, Medicinal