Title
Dicitrinones E and F, citrinin dimers from the marine derived fungus Penicillium citrinum HDN-152-088
Author
Lu Wang, Changlong Li, Guihong Yu, Zichao Sun, Guojian Zhang, Qianqun Gu, Tianjiao Zhu, Qian Che, Huashi Guan, Dehai Li
Year
2019
Journal
Tetrahedron Letters
Abstract
Two new citrinin dimers named dicitrinones E and F (1 and 2), together with one biogenetically related known citrinin monomer (3), were isolated from the marine derived fungus Penicillium citrinum HDN-152-088. All structures including the absolute configurations were elucidated on the basis of comprehensive spectroscopic data, and assisted by ECD calculations. Among them, compounds 1 and 2 belong to the class of citrinin dimers with a rare carbon-bridged C-7/C-7′ linkage. Compound 1 displayed antioxidant activity with IC50 value of 23.73 μM.
Instrument
J-715
Keywords
Circular dichroism, Stereochemistry, Absolute configuration, Agriculture and environmental, Pharmaceutical, Medicinal, Biochemistry