Title
Lignans from Saururus chinensis with Inhibitory Effects on Nitric Oxide Production
Author
Qinghao Jin, Jin Woo Lee, Jun Gu Kim, Dongho Lee, Jin Tae Hong, Youngsoo Kim, Mi Kyeong Lee, Bang Yeon Hwang
Year
2019
Journal
Journal of Natural Products
Abstract
Three biogenetically related ent-sauchinone-type lignans (1–3), four 8-O-4′-type neolignans (4–7), a diaryldimethylbutane lignan (8), and a cyclic carbonate (9), along with 12 known compounds, have been isolated from a methanol extract of the aerial parts of Saururus chinensis. The structures of the new compounds (1–9) were determined by analysis of their 1D and 2D NMR spectra, HRESIMS, and ECD data. A putative biosynthetic pathway for the three ent-sauchinone-type lignans (1–3) was postulated. Compounds 1, 7, and 10 showed inhibitory effects on LPS-induced NO production in RAW 264.7 cells with IC50 values of 5.6, 8.6, and 9.2 μM, respectively.
Instrument
J-710
Keywords
Circular dichroism, Absolute configuration, Natural products, Pharmaceutical, Biochemistry