Title
Structure elucidation {spectroscopic, single crystal X-ray diffraction and computational DFT studies} of new tailored benzenesulfonamide derived Schiff base copper(II) intercalating complexes: Comprehensive biological profile {DNA binding, pBR322 DNA cleavage, Topo I inhibition and cytotoxic activity}
Author
Zeenat Afsan, Thierry Roisnel, Sartaj Tabassum, Farukh Arjmand
Year
2019
Journal
Bioorganic Chemistry
Abstract
New tailored copper(II)–based intercalating complexes [Cu(L1)2] (1) and [Cu(L2)2] (2) were synthesized from Schiff base scaffold HL1 and HL2(E)-4-(2-((2-hydroxy-3-methoxybenzylidene)amino)ethyl)benzenesulfonamide and (E)-4-(2-((2-hydroxybenzylidene)amino)ethyl)benzenesulfonamide, respectively. The structure elucidation of complexes 1 and 2 was carried out by employing various spectroscopic techniques viz., FT–IR, UV–vis, ESI–MS, EPR and single X–ray crystal diffraction studies. The complexes 1 and 2 were crystallized in monoclinic P21/n and triclinic P–1 space group, respectively possessing square planar geometry around Cu(II) coordinated with N,O–donor Schiff base ligands. An analysis of Hirshfeld surfaces of complexes 1 and 2 were performed to ascertain different intra and intermolecular non–covalent interactions (H–bonding, CH⋯ π
Instrument
J-815
Keywords
Circular dichroism, DNA structure, Ligand binding, Biochemistry, Organic chemistry