Title
Hyalodendrins A and B, New Decalin-Type Tetramic Acid Larvicides from the Endophytic Fungus Hyalodendriella sp. Ponipodef12
Author
Ziling Mao, Weixuan Wang, Ruixue Su, Gan Gu, Zhi Long Liu, Daowan Lai, Ligang Zhou
Year
2020
Journal
molecules
Abstract
Two new decalin/tetramic acid hybrid metabolites, hyalodendrins A (1) and B (2) were isolated from plant endophytic fungus Hyalodendriella sp. Ponipodef12. The structures of the new compounds were elucidated by analysis of the spectroscopic data, including NMR, HRMS and ECD, and by chemical conversion. Compounds 1 and 2 were phomasetin analogues, and both showed potent larvicidal activity against the fourth-instar larvae of Aedes aegypti with the median lethal dose (LC50) values of 10.31 and 5.93 μg/mL, respectively.
Full Article
Instrument
J-810
Keywords
Circular dichroism, Stereochemistry, Absolute configuration, Agriculture and environmental