PR-4088 Prep SFC Features
The PR-4088 Prep SFC system is designed for large-scale throughput with 21 mm or 30 mm columns to maximum sample purification. This system is versatile enough to be used for smaller scale prep using 10mm columns. Interchangeable modifier pumps can be configured to give highly accurate modifier compositions. ChromNAV provides complete integrated control for flow rate, temperature, sample injection, and fractionation.
Fast CO2 Delivery
Preparative scale CO2 delivery of up to 150 mL/min, or up to 200 mL when combined with a modifier co-solvent.
Maximum Sample Preparation
Using columns from 10 to 30 mm ID, the PR-4088 Prep System can be used for separation and purification from 100mg to 100g per day of sample material. High productivity with stacked injections.
Sample separation for Chiral & Achiral
PR-4088 Prep System is excellent for both Chiral and Achiral sample preparation.
Powerful SFC Management Tool
Using ChromNAV software the PR-4088 Prep can be used with a wide variety of fraction collection methods, including time window, slope, and/or threshold, to achieve high throughput stack injection.
Complete Audit trail to monitor campaigns
ChromNAV controls your campaign; monitors the individual chromatograms, complete sets of stacked injections, and pressure and temperature profiles throughout the system.
High-Throughput Sample
Several fraction collection regimes for use with larger sample bottles for larger-scale purification.
Accurate Chromatography with Large Volume Injections
PR-4088 uses the Patented DLI (Dual Line Injection) to ensure excellent chromatography when making large-volume injections.
8 Fraction Sample Collection Unit
The PR-4088 fraction collection unit includes the patented dynamic back pressure regulator and 8 individual cyclone separators with a separate waste line. Fraction control allows sequential or stacked injection, with the option to collect the fractions between peaks to ensure there is no sample loss. Recoveries are typically in the region of 95% or better with negligible cross-contamination between fractions.
Widest Range of Detection Schemes
The PR-4088 SFC System can be used with a single detector or combination of detectors to control fractionation, including Mass Spec, UV-Vis, PDA, and chiral (circular dichroism). For applications requiring the utmost sensitivity, JASCO has designed the first high-pressure flow cell designed for the FP-4020 fluorescence detectors making them compatible with SFC.
Semi-Preparative SFC
The semi-prep SFC has capacity for larger scale purification, but can still be used for analytical scale method development. The system is optimized for 10mm and 20mm ID columns. The open-bed fraction collector can be triggered on time, threshold or slope based on signals from up to 4 different detectors signals including UV, PDA, fluorescence, CD and/or MS. The macro cyclone separators provide simple gas-liquid separation for excellent fraction recoveries typically greater than 95%. Fractions can be collected using an open bed fraction collector or an 8-way valve.
Semi-Preparative Flow Rates
Using columns for 10 mm and 20mm ID, the semi-preparative SFC System can be used for separation and purification of 10 to 100 grams of sample material.
Typical Purification Range
Semi-preparative flow rates from 3mL/min to 50mL/min for purification of up to 100g of sample.
Column Switching
Six or ten column switching for automatic selection.
Solvent Switching
Six or ten modifier solvent selection.
High-Capacity Column Oven
High capacity column oven for up to three 20mm columns.
High Recovery Rate
Patented individual MCS MicroCyclone fraction collection system for sample collection without cross contamination.
Powerful Software
ChromNav for simple control with powerful fractionation algorithms.
Wide Range of Detectors
Wide range of detectors including UV-visible, Photo Diode Array (PDA), Mass Spectrometer (MS), Flame Ionization Detector (FID), and Circular Dichroism (CD) for chiral applications. For applications that require the utmost sensitivity, JASCO has designed the first high-pressure flow cell for the FP-4020 fluorescence detector making it compatible with SFC.
High-Throughput Fraction Collection System
Fraction collection with open bed fraction collector.
Dynamic Back Pressure Regulator
Patented dynamic back pressure regulator for accurate control of pressure for accurate and reproducible separations.
Hybrid SFC System
The SFC Hybrid system crosses the divide between analytical SFC and preparative SFC, offering the best of both techniques. With flow rates from 1 mL/min up to 20 mL/min this system can be used with 4.6mm columns for high-quality analytical separations and with 10 mm columns for excellent sample isolation and purification.
Analytical to Semi-Preparative Flow Rates
Using columns from 4.6 to 10 mm ID, the Hybrid SFC System can be used for the separation and purification of up to several 100 mg of sample material.
Typical Purification Range
Analytical and semi-preparative flow rates from 1mL/min to 20mL/min for purification of samples up to 100s of mg.
Column Switching
Six or ten column switching for automatic selection for method development.
Solvent Switching
Six or ten modifier solvent selection for method development.
High-Capacity Column Oven
High-capacity column oven for up to ten 10mm columns, with an option for use of up to 3 column ovens for even greater flexibility.
High Recovery Rate
Patented individual MCS MicroCyclone fraction collection system for sample collection without cross-contamination.
Powerful Software
ChromNav for simple control with powerful fractionation algorithms.
Wide Range of Detectors
Wide range of detectors including UV-visible, Photo Diode Array (PDA), Mass Spectrometer (MS), Flame Ionization Detector (FID), and Circular Dichroism (CD) for chiral applications. For applications that require the utmost sensitivity, JASCO has designed the first high-pressure flow cell for the FP-4020 fluorescence detector making it compatible with SFC.
High-Throughput Fraction Collection System
Fraction collection with open bed fraction collector.
Dynamic Back Pressure Regulator
Patented dynamic back pressure regulator for accurate control of pressure for accurate and reproducible separations.