Title
Adenine oligomer directed synthesis of chiral gold nanoparticles
Author
Nam Heon Cho, Young Bi Kim, Yoon Young Lee, Sang Won Im, Ryeong Myeong Kim, Jeong Won Kim, Seok Daniel Namgung, Hye-Eun Lee, Hyeohn Kim, Jeong Hyun Han, Hye Won Chung, Yoon Ho Lee, Jeong Woo Han & Ki Tae Nam
Year
2022
Journal
Nature Communications
Abstract
Precise control of morphology and optical response of 3-dimensional chiral nanoparticles remain as a significant challenge. This work demonstrates chiral gold nanoparticle synthesis using single-stranded oligonucleotide as a chiral shape modifier. The homo-oligonucleotide composed of Adenine nucleobase specifically show a distinct chirality development with a dissymmetric factor up to g ~ 0.04 at visible wavelength, whereas other nucleobases show no development of chirality. The synthesized nanoparticle shows a counter-clockwise rotation of generated chiral arms with approximately 200 nm edge length. The molecular dynamics and density functional theory simulations reveal that Adenine shows the highest enantioselective interaction with Au(321)R/S facet in terms of binding orientation and affinity. This is attributed to the formation of sequence-specific intra-strand hydrogen bonding between nucleobases. We also found that different sequence programming of Adenine-and Cytosine-based oligomers result in chiral gold nanoparticles’ morphological and optical change. These results extend our understanding of the biomolecule-directed synthesis of chiral gold nanoparticles to sequence programmable deoxyribonucleic acid and provides a foundation for programmable synthesis of chiral gold nanoparticles.
Full Article
Instrument
J-815
Keywords
morphology, chiral, nanoparticle,