Higher-Order Structure, Stability, and Similarity Assessment of VHH Antibodies Using CD Spectroscopy | POSTER
Introduction
- VHH* antibodies are attracting attention as next-generation modalities
- Higher-order structure (HOS) is a critical quality attribute (CQA)
responsible for VHH antibody functions - CD spectroscopy is a suitable technique for protein HOS assessment
*Variable domain of heavy chain antibodies
Keywords
Circular Dichroism, CD, Higher Order Structure, HOS, Secondary Structure, SSE, VHH antibodies
References
Satoko Suzuki1, Emina Ikeuchi2, Taiji Oyama1, Ai Yamane1, Yasuo Horiguchi1, Ken-ichi Akao1
Akikazu Murakami3, András Micsonai4, József Kardos4, Koushi Nagamori1, and Kouhei Tsumoto2
- JASCO Corporation, Hachioji, Tokyo 192-8537, Japan
- Department of Chemistry & Biotechnology, School of Engineering, The University of Tokyo, Bunkyo-ku, Tokyo 113-8656, Japan
- RePHAGEN Co., Ltd., Uruma, Okinawa 904-2234, Japan
- ELTE NAP Neuroimmunology Research Group, Department of Biochemistry, Institute of Biology, ELTE Eötvös Loránd University, Budapest H-1117, Hungary
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