Introduction

Alkylphenones are often used for evaluating HPLC systems because of their reasonable retention times on ODS columns and easy separation with a water/acetonitrile mobile phase.

This report outlines the ultra-high speed analysis of alkylphenones analysis by Ultra High-performance Liquid Chromatography (UHPLC) using with a PDA detector (high-speed data acquisition of 100 spectra/sec).

Experimental

Results

Figure 1 3D chromatogram of an alkylphenone standard mixture containing 9 components. All of the alkylphenones were successfully separated and detected within 12 seconds.

1: Acetanilide, 2: Acetophenone,3: Propiophenone, 4: Butyrophenone, 5: Benzophenone, 6: Valerophenone, 7: Hexanophenone, 8: Heptanophenone, 9: Octanophenone.