1,3-Thiazolium-4-aminides: Syntheses and Characterization of Fluorescent Mesoionic Compounds

January 5, 2022

Title

1,3-Thiazolium-4-aminides: Syntheses and Characterization of Fluorescent Mesoionic Compounds

Author

Alena Therese Storm, Mimoza Gjikaj, Jan C. Namyslo, Jorg Adams, Andreas Schmidt

Year

2021

Journal

European Journal of Organic Chemistry

Abstract

A series of mesoionic 1,3-thiazolium-4-aminides was synthesized starting from thioamides and chloroacetonitrile via cyanomethylbenzimidothioates which were cyclized by benzoylchloride. Depending on the reaction conditions 4-amino-1,3-thiazolium salts and 4-N-benzamido-1,3-thiazolium salts were obtained (X-ray structure analysis). Substitution of the amino groups with benzoyl chloride gave a series of the title mesoionic compounds (X-ray structure analysis) which were examined spectroscopically. Negative solvatochromism was found and temperature-dependent as well as time-resolved fluorescence measurements were made. Long lifetimes of the excited states (30–50 ns) were detected. Calculated frontier orbital profiles gain insight into the characteristics of 1,3-thiazolium-4-aminides as conjugated mesomeric betaines.

Instrument

V-670

Keywords

1,3-thiazolium-4-aminides, 4-amino-1,3-thiazolium salts, 4-N-benzamido-1,3-thiazolium salts, positive change, negative change