Title
13,14-seco-Withanolides from Physalis minima with Potential Anti-inflammatory Activity
Author
Ru Lin, Yu-Zhou Guan, Rui-Jun Li, Xiao-Ming Xu, Jian-Guang Luo, Ling-Yi Kong
Year
2016
Journal
Chemistry and Biodiversity
Abstract
Four new 13,14-seco-withanolides, minisecolides A-D (1–4), together with three known analogues 5–7, were isolated from the whole plants of Physalis minima. The structures of new compounds were determined on the basis of spectroscopic analysis, including 1H-, 13C-NMR, 2D-NMR (HMBC, HSQC, ROESY), and HR-ESI-MS. Evaluation of all isolates for their inhibitory effects on nitric oxide (NO) production were conducted on lipopolysaccaride(LPS)-activated RAW264.7 macrophages. Compounds 2, 3, 5, and 6 showed inhibitory activities, especially for compound 5 with IC50 value of 3.87 μm.
Instrument
J-810
Keywords
Circular dichroism, Stereochemistry, Medicinal