Leah Pandiscia, PhD
March 24, 2020
Protein–protein interactions control a wide variety of natural biological processes. α-Helical coiled coils frequently mediate such protein–protein interactions. Due to… Continue reading De Novo Designed Protein-Interaction Modules for In-Cell Applications
Leah Pandiscia, PhD
March 24, 2020
Dual glucagon-like peptide-1/glucagon receptor agonists have emerged as promising candidates for the treatment of diabetes and obesity. Issues of degradation… Continue reading Self-Assembly of Exendin-4-Derived Dual Peptide Agonists is Mediated by Acylation and Correlated to the Length of Conjugated Fatty Acyl Chains
Leah Pandiscia, PhD
March 24, 2020
Inflammatory bowel diseases (IBDs) are a growing health concern. Enterobacteria, including Escherichia coli, bloom to high levels in the gut during… Continue reading The Cu(II) reductase RclA protects Escherichia coli against the combination of hypochlorous acid and intracellular copper
Leah Pandiscia, PhD
March 24, 2020
A supramolecular complex (1×C60) was prepared by assembling (C60‐Ih)[5,6]fullerene (C60) with the dinuclear Tb3+ triple‐decker complex [(TPP)Tb(Pc)Tb(TPP)] (1: Tb3+ =… Continue reading Manipulation of the Coordination Geometry along the C4 Rotation Axis in a Dinuclear Tb3+ Triple‐Decker Complex via a Supramolecular Approach
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 27, 2020
The coronavirus nucleocapsid (N) protein binds viral RNA to form the ribonucleocapsid and regulate RNA synthesis. The interaction of N protein with viral RNA was investigated… Continue reading Characterisation of the RNA binding properties of the coronavirus infectious bronchitis virus nucleocapsid protein amino-terminal region
Leah Pandiscia, PhD
March 27, 2020
Leah Pandiscia, PhD
March 27, 2020
Leah Pandiscia, PhD
March 27, 2020
The helicase from severe acute respiratory syndrome coronavirus (SARS‐CoV) possesses NTPase, duplex RNA/DNA‐unwinding and RNA‐capping activities that are essential for… Continue reading Differential Inhibitory Activities and Stabilisation of DNA Aptamers against the SARS Coronavirus Helicase
Leah Pandiscia, PhD
March 27, 2020
Leah Pandiscia, PhD
March 27, 2020
Leah Pandiscia, PhD
March 27, 2020
Leah Pandiscia, PhD
March 27, 2020
Leah Pandiscia, PhD
March 27, 2020
Leah Pandiscia, PhD
March 27, 2020
Leah Pandiscia, PhD
March 27, 2020
SARS (severe acute respiratory syndrome) has been one of the most severe viral infectious diseases last year and still remains… Continue reading Quaternary Structure of the Severe Acute Respiratory Syndrome (SARS) Coronavirus Main Protease
Leah Pandiscia, PhD
March 27, 2020
Recently, we designed and assembled protein nanobuilding blocks (PN-Blocks) from an intermolecularly folded dimeric de novo protein called WA20. Using this dimeric… Continue reading Hyperstable De Novo Protein with a Dimeric Bisecting Topology
Leah Pandiscia, PhD
March 24, 2020
Leah Pandiscia, PhD
March 24, 2020