Found 9617 Results / Page 204 of 481
2017 / Biochimica et Biophysica Acta (BBA) - Biomembranes
For the first time, the photoisomerization of a diarylethene moiety (DAET) in peptideconjugates was used to probe the effects of molecular… Continue reading Flexibility vs rigidity of amphipathic peptide conjugates when interacting with lipid bilayers
2018 / PLoS ONE
Low expression and instability are significant challenges in the recombinant production of therapeutic peptides. The current study introduces a novel… Continue reading Human αB-crystallin as fusion protein and molecular chaperone increases the expression and folding efficiency of recombinant insulin
2018 / International Journal of Biological Macromolecules
Carbohydrate binding modules (CBMs) are non-catalytic domains within larger multidomain polypeptides. The CelH from Ruminoclostridium (Clostridium) thermocellum contains a family 11 CBM (RtCBM11) with high binding… Continue reading Engineering the affinity of a family 11 carbohydrate binding module to improve binding of branched over unbranched polysaccharides
2018 / Acta Tropica
Chloroquine (CQ) has been used for decades as the primary chemotherapeutic drugfor the treatment of malaria. The emergence of drug resistance in Plasmodiumfalciparum has been considered to… Continue reading In silico modeling of Plasmodium falciparum chloroquine resistance transporter protein and biochemical studies suggest its key contribution to chloroquine resistance
2018 / PLOS Neglected Tropical Diseases
Parasitic nematodes produce an unusual class of fatty acid and retinol (FAR)-binding proteins that may scavenge host fatty acids and… Continue reading Ligand binding properties of two Brugia malayi fatty acid and retinol (FAR) binding proteins and their vaccine efficacies against challenge infection in gerbils
2018 / Journal of Inclusion Phenomena and Macrocyclic Chemistry
A (diethylamino)coumarin-modified β-cyclodextrin (1) increased its fluorescence intensity upon guest binding in an aqueous media, and this phenomenon was used… Continue reading Highly selective binding behavior of (diethylamino)coumarin-modified β-cyclodextrin with bile acids
2018 / Applied Microbiology and Biotechnology
Peroxidases are well-known biocatalysts produced by all organisms, especially microorganisms, and used in a number of biotechnological applications. The enzyme… Continue reading Characterization and use of a bacterial lignin peroxidase with an improved manganese-oxidative activity
2018 / Molecules
In contrast to Z-DNA that was stabilized and well-studied for its structure by chemical approaches, the stabilization and structural study… Continue reading 2′-O-Methyl-8-methylguanosine as a Z-Form RNA Stabilizer for Structural and Functional Study of Z-RNA
2018 / Bioscience Reports
Insulin-degrading enzyme (IDE) is a zinc metalloprotease that selectively degrades biologically important substrates associated with type 2 diabetes and Alzheimer’s… Continue reading Enzyme Kinetics from Circular Dichroism of Insulin Reveals Mechanistic Insights into the Regulation of Insulin-degrading Enzyme
2018 / PLoS ONE
BAF250a and BAF250b are subunits of the SWI/SNF chromatin-remodeling complex that recruit the complex to chromatin allowing transcriptional activation of… Continue reading Domain architecture of BAF250a reveals the ARID and ARM-repeat domains with implication in function and assembly of the BAF remodeling complex
2018 / ACS Applied Biomaterials
Self-assembly is one of the important and fruitful method to develop various biomaterials especially hydrogels from biologically important small molecules.… Continue reading Biocytin based pH-stimuli responsive supramolecular multivariant hydrogelator for potential applications
2018 / molecules
We report experimental tests of whether non-rigid, π-conjugated luminophores in the photoexcited (S1) and ground (S0) states dissolved in achiral liquids… Continue reading Questions of Mirror Symmetry at the Photoexcited and Ground States of Non-Rigid Luminophores Raised by Circularly Polarized Luminescence and Circular Dichroism Spectroscopy: Part 1. Oligofluorenes, Oligophenylenes, Binaphthyls and Fused Aromatics
2018 / molecules
Three new meliacarpinin-type limonoids, toosendanes A–C (1–3), along with three, known meliacarpinins (4–6) were isolated from the bark of Melia toosendan.… Continue reading Meliacarpinin-Type Limonoids from the Bark of Melia toosendan
2019 / Biochimica et Biophysica Acta (BBA) - General Subjects
Injection localized amyloidosis is one of the most prevalent disorders in type II diabetes mellitus (TIIDM) patients relying on insulin… Continue reading Insulin adsorption onto zinc oxide nanoparticle mediates conformational rearrangement into amyloid-prone structure with enhanced cytotoxic propensity
2018 / PLoS ONE
Antimicrobial peptides (AMPs) are short and generally positively charged peptides found in a wide variety of organisms. CSαβ defensins are… Continue reading Recombinant AfusinC, an anionic fungal CSαβ defensin from Aspergillus fumigatus, exhibits antimicrobial activity against gram-positive bacteria
2018 / Metallomics
Polyhistidine triad proteins, which participate in Zn2+ uptake in Streptococcus pneumoniae, contain multiple copies of the HxxHxH (histidine triad motif)… Continue reading Pneumococcal histidine triads – involved not only in Zn2+, but also Ni2+binding?
2018 / The Journal of Antibiotics
A new piperazine derivative designated helvamide was isolated as a pair of rotamers (1 and 2) from the culture broth of the… Continue reading Helvamide, a new inhibitor of sterol O-acyltransferase produced by the fungus Aspergillus nidulans BF-0142
2018 / Scientific Reports
Over 12% of the world’s health resources are spent on treating diabetes, as high blood glucose is the third cause… Continue reading Size Exclusion Chromatography Method for Purification of Nicotinamide Mononucleotide (NMN) from Bacterial Cells
2019 / Scientific Reports
Detailed analysis of biopharmaceuticals is crucial for safety, efficacy and stability. Aptamers, which are folded, single-stranded oligonucleotides, can be used… Continue reading Aptamers as quality control tool for production, storage and biosimilarity of the anti-CD20 biopharmaceutical rituximab
2017 / Scientific Reports
Marine debris is widely recognized as a global environmental problem. One of its main components, microplastics, has been found in… Continue reading Microplastics in Spanish Table Salt
