KnowledgeBase Articles

A deep-ultraviolet resonance Raman (DUVRR) spectroscopic method has been used to study the secondary structural changes of a therapeutic monoclonal… Continue reading Secondary structure assessment of formulated bevacizumab in the presence of SDS by deep ultraviolet resonance Raman (DUVRR) spectroscopy

Metal–protein interactions are not necessarily tight in many transient biological processes, such as cellular signaling, enzyme regulation, and molecular recognition.… Continue reading Binding thermodynamics of metal ions to HIV-1 ribonuclease H domain

As current anticancer drugs have limitations, researchers have sought novel anti-cancer agents with high specificity and fewer side effects to… Continue reading A Novel Anti-cancer Peptide Extracted from Gynura pseudochina Rhizome: Cytotoxicity Dependent on Disulfide Bond Formation

Protein pores are highly specific in binding to chiral substrates and in catalysing stereospecific reactions, because their active pockets are… Continue reading Homochiral porous nanosheets for enantiomer sieving

A label-free light-up fluorescent sensing strategy using hybridization chain reaction (HCR) amplification and DNA triplex assembly has been developed. Remarkably,… Continue reading A label-free light-up fluorescent sensing platform based upon hybridization chain reaction amplification and DNA triplex assembly

Captopril (CAP), an angiotensin-converting enzyme inhibitor, widely used for the treatment of hypertension. The current study was undertaken to explore… Continue reading Probing of the binding profile of anti-hypertensive drug, captopril with bovine serum albumin: A detailed calorimetric, spectroscopic and molecular docking studies

Anti-vascular endothelial growth factor (anti-VEGF) therapy applied to solid tumors is a promising strategy, yet, the challenge to deliver these agents at… Continue reading Alginate hydrogel improves anti-angiogenic bevacizumab activity in cancer therapy

Very recently, synthesis of a stabilizer-free copper nanocluster (CuNC) with enhanced catalytical activity was proposed by simply refluxing copper salt… Continue reading Characterizing optical properties, composition of stabilizer-free copper nanoclusters and its interaction with bovine serum albumin

Racemates often have lower solubility than enantiopure compounds, and the mixing of enantiomers can enhance the aggregation propensity of peptides.… Continue reading Suppression of Oligomer Formation and Formation of Non-Toxic Fibrils upon Addition of Mirror-Image Aβ42 to the Natural l-Enantiomer

Chemokines are important mediators of immunological responses during inflammation and under steady-state conditions. In addition to regulating cell migration, some… Continue reading In vitro and in vivo antimicrobial activity of a synthetic peptide derived from the C-terminal region of human chemokine CCL13 against Pseudomonas aeruginosa

The preparation of histidine enriched dendritic peptide amphiphiles and their self-assembly into multicomponent pH-switchable supramolecular polymers is reported. Alternating histidine… Continue reading Tuning the pH-Switch of Supramolecular Polymer Carriers for siRNA to Physiologically Relevant pH

Chirality strongly influences many biological properties of materials, such as cell accumulation, enzymatic activity, and toxicity. In the past decade,… Continue reading Enantioselective cytotoxicity of ZnS:Mn quantum dots in A549 cells

Cytosine-rich oligonucleotides are capable of forming complex structures known as i-motif with increasingly studied biological properties. The study of sequences prone to… Continue reading i-motif structures in long cytosine-rich sequences found upstream of the promoter region of the SMARCA4 gene

Two chiral Cu(II) complexes of [Cu2(R-L)2](PF6)2·2C2H5OH (1) and [Cu2(S-L)2](PF6)2·2C2H5OH (2) (HL = 2-(Bis(quinolin-2-ylmethyl)amino)-1-propanol) were designed and synthesized to serve as… Continue reading Preparation, characterization and biological evaluation of two chiral binuclear copper(II) complexes

3-Mercaptopropionic Acid-modified CdTe quantum dots (QDs) were synthesized and characterized by infrared, fluorescence, and ultraviolet–visible absorption spectra and Nano-ZetaSizer measurements.… Continue reading Spectroscopic investigation of the effects of aqueous-phase prepared CdTe quantum dots on protein hemoglobin at the molecular level

Nickel(II), zinc(II) and cadmium(II) complexes of two hexapeptides ADAAAC-NH2 and AADAAC-NH2 containing terminal amino, separate aspartyl carboxylate and cysteinyl thiolate donor functions… Continue reading Nickel(II), zinc(II) and cadmium(II) complexes of peptides containing separate aspartyl and cysteinyl residues

100K is an important scaffolding protein of adenoviruses including fowl adenovirus serotype 4 (FAdV-4) that causes inclusion body hepatitis-hydropericardium syndrome (IBH-HPS) in poultry. 100K carries out… Continue reading Overexpression and characterization of the 100K protein of Fowl adenovirus-4 as an antiviral target

To delineate the commonalities and differences in gaseous ligand discrimination among the heme-based sensors with Heme Nitric oxide/OXygen binding protein (H-NOX) scaffold, the… Continue reading Gaseous ligand selectivity of the H-NOX sensor protein from Shewanella oneidensis and comparison to those of other bacterial H-NOXs and soluble guanylyl cyclase

We have designed de novo and synthesized eight 26-residue all D-conformation amphipathic α-helical cationic antimicrobial peptides (AMPs), four with “specificity… Continue reading Role of positively charged residues on the polar and non-polar faces of amphipathic α-helical antimicrobial peptides on specificity and selectivity for Gram-negative pathogens

Self-assembly of chiral nanostructures is of considerable interest, since the ability to control the chirality of these structures has direct… Continue reading Reconfigurable Chiral Self-Assembly of Peptides through Control of Terminal Charges